1 Design and Synthesis of p 25 / CDK 5 Inhibitors Based on Roscovitine
نویسندگان
چکیده
In Alzheimer’s disease (AD) two aberrant proteins amyloid plaques (Aβ) and Neurofibrillary tangles (NFTs) have been identified. Aβ peptide is produced from soluble amyloid precursor protein (SAPP) as a result of two sequential proteolysis steps by β-secretase [beta-site Amyloid Precursor Protein Cleaving Enzyme (BACE)] then γ-secretase. NFTs, are made up of several proteins but primarily hypophosphorylated Tau. P25/Cyclin dependant kinase 5 (p25/CDK-5), hypophosphorylates Tau at Ser 205 by using ATP as a phosphate source. This project seeks to design and synthesize inhibitors of p25/Cdk-5 based on the ATP binding site. 2 Synthesis, Physicochemical Characterization and Electronic Band Structure Calculations for CuInS2:Mn Kathryn B. Knorr, Jonathan W. Lekse, Heather A. Figore, Jeffry D. Madura and Jennifer A. Aitken Department of Chemistry and Biochemistry, Duquesne University
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